![]() The One Occurrence Per Sequence option (about ten times as much) and is This option takes much more computer time than This option can also be used to discover repeats In that case, the motifs found will be much more accurate than using one ![]() You suspect that motifs repeat multiple times within a single sequence. Non-overlapping occurrences of each motif. Any Number of Repetitions (anr) MEME assumes each sequence may contain any number of If they do not occur in every input sequence. This option is the fastestĪnd most sensitive but the motifs returned by MEME will be "blurry" (less specific) One Occurrence Per Sequence (oops) MEME assumes that each sequence in the dataset containsĮxactly one occurrence of each motif. Sensitive to weak motifs present in all of the sequences. Occurrence Per Sequence option (about twice as much) and is slightly less This option takes more computer time than the One Motifs found will be more accurate than using the One Occurrence per Some motifs may be missing from some of the sequences. This option is useful when you suspect that Zero or One Occurrence per Sequence (zoops) MEME assumes that each sequence may contain at most one Selecting the correct type ofĭistribution improves the sensitivity and quality of the motif search. This is where you tell MEME how you believe occurrences of the motifsĪre distributed among the sequences. Primary sequences compared to the control sequences. Hypergeometric distribution to determine the relative enrichment of sites in the In Differential Enrichment mode, MEME optimizes an objective function based on the We modify their approach to search for the "best" initial motif width, andįor more details. Simple discriminative prior "D" described in Section 3.5 of Position-specific prior to inform the search. MEME then searches the first set of sequences for motifs using the In Discriminative mode, we first calculate a You provide two sets of sequences and MEME discovers motifs thatĪre enriched in the first (primary) set relative to the second (control) set. Given in a "Custom background model" that you may provide (see Advanced options). Enrichment is measured relative to a (higher order) random model based onįrequencies of the letters in your sequences, or relative to the frequencies You provide one set of sequences and MEME discovers motifs enriched Program by clicking on a button in the output report of a different MEME Suite program.īy selecting this option you will input the sequences sent by that program. Submitted sequences This option is only available when you have invoked the current The full list of available sequence databases and their descriptionsĬan be viewed HERE. Where you can select the particular database and version desired, respectively. Sequence database from the list below it. ![]() Databases (select category) When this option is available you may first select a category of Upload BED file When this option is available you may upload a file containing Upload sequences When this option is available you may upload a file containing Type in sequences When this option is available you may directly input multiple Click on the menu at the left to see which of the following sequence input methods are available.
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